99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein

Multidrug Resistance Protein (P-Glycoprotein; MDR1)

Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma.

Intrinsic and/or acquired resistance to chemotherapy is the major obstacle to overcome in the treatment of patients with ovarian carcinoma. The aim of the present study was to investigate the prognostic value of drug resistance-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), canalicular multispecific organic anion transporter (c-MOAT/MRP2), and lung ...

P-glycoprotein, multidrug resistance and protein kinase C.

The multidrug resistant (MDR) phenotype is a well-studied subject that has been recognized as a determinant underlying specific types of drug resistance in human cancer. Although it is clear that the P-glycoprotein plays a major role in MDR, it is not clear whether post-translational modifications such as phosphorylation have any major impact on its modulation. The laboratory of Dr. Bruce Chabn...

How to probe clinical tumour samples for P-glycoprotein and multidrug resistance-associated protein.

INTRODUCTION ONE FACTOR which supposedly limits the effectiveness of chemotherapy in cancer treatment is a reduced net uptake of cytostatic drug into the tumour cells, caused by the overexpression of plasma membrane drug transporters, leading to a multidrug resistant (MDR) phenotype. It has now been shown that two drug transporter proteins affect the net uptake of lipophilic natural product age...

The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer

BACKGROUND To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and the clinico-pathological features. METHODS The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determin...